Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 3/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.31 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11962993 | 0.83 | PDE2A (0.40) | PDE2ALIPESCN9ARAF1BRAF | |
| SCHEMBL6903551 | 0.81 | PDE2A (0.36) | PDE2ALIPESCN9ARAF1BRAF | |
| SCHEMBL1660071 | 0.80 | PDE2A (0.35) | PDE2ALIPESCN9ARAF1BRAF | |
| SCHEMBL6903790 | 0.78 | — | — | |
| SCHEMBL14718267 | 0.70 | KCNN4 (0.32) | SCN9A | |
| SCHEMBL6904513 | 0.69 | SCN9A (0.36) | SCN9A | |
| SCHEMBL14718861 | 0.69 | PDE2A (0.37) | PDE2ASCN9ARAF1BRAFSCN10A | |
| SCHEMBL1661829 | 0.69 | KCNN4 (0.33) | SCN9A | |
| SCHEMBL1661602 | 0.68 | SCN9A (0.32) | SCN9A | |
| SCHEMBL1660015 | 0.67 | PDE2A (0.36) | PDE2ASCN9ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | disclosed |