Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.33 |
| ▸ | RAF1 | P04049 | 6/20 | 0.33 |
| ▸ | BRAF | P15056 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.31 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659966 | 0.81 | PDE2A (0.44) | PDE2ASCN9ARAF1BRAFKDM4E | |
| SCHEMBL1658564 | 0.80 | PDE2A (0.32) | PDE2ASCN9ARAF1BRAFLIPE | |
| SCHEMBL6903557 | 0.79 | PDE2A (0.40) | PDE2ASCN9ARAF1BRAFKDM4E | |
| SCHEMBL11963054 | 0.72 | POLB (0.38) | SCN9ARAF1BRAFKDM4EMAPT | |
| SCHEMBL11963055 | 0.70 | POLB (0.41) | SCN9ARAF1BRAFKDM4EMAPT | |
| SCHEMBL19282960 | 0.62 | OPRM1 (0.52) | THRB | |
| SCHEMBL6904513 | 0.62 | SCN9A (0.36) | SCN9AMEN1KMT2A | |
| SCHEMBL14718861 | 0.62 | PDE2A (0.37) | PDE2ASCN9ARAF1BRAFKDM4E | |
| SCHEMBL1661829 | 0.62 | KCNN4 (0.33) | SCN9A | |
| SCHEMBL11962993 | 0.61 | PDE2A (0.40) | PDE2ASCN9ARAF1BRAFLIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | disclosed |