Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MPI | P34949 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10924404 | 1.00 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL12438887 | 0.78 | ALDH1A1 (0.52) | ALDH1A1TSHRMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL13954093 | 0.78 | ALDH1A1 (0.52) | ALDH1A1TSHRMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL9583273 | 0.78 | ALDH1A1 (0.52) | ALDH1A1TSHRMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL29367737 | 0.76 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL8995499 | 0.76 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL2160910 | 0.76 | FGF23 (0.53) | ALDH1A1TSHRMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL16317365 | 0.76 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL406151 | 0.76 | FGF23 (0.53) | ALDH1A1TSHRMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL1396871 | 0.76 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPTL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987269-B2 | Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor | HUTCHISON MEDIPHARMA LIMITED (CN) | 2015-03-24 | — | — | US | disclosed |