Sugi Predict

Sugi Predict / Targets / FGF23

FGF23

Fibroblast growth factor 23 · Q9GZV9 · FGF23 on Sugi Atlas →

1,105 patent compounds predicted against FGF23, 576 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL762978 SCHEMBL762978 0.57 4/20
SCHEMBL2161965 SCHEMBL2161965 0.57 4/20
SCHEMBL2161969 SCHEMBL2161969 0.57 4/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL28407082) 0.55 4/20
SCHEMBL9478053 SCHEMBL9478053 0.46 4/20
SCHEMBL9478055 SCHEMBL9478055 0.46 4/20
SCHEMBL2358162 SCHEMBL2358162 0.41 4/20
SCHEMBL2358163 SCHEMBL2358163 0.41 4/20
SCHEMBL16439209 SCHEMBL16439209 0.55 3/20
SCHEMBL3378277 SCHEMBL3378277 0.53 3/20
SCHEMBL4446330 SCHEMBL4446330 0.53 3/20
SCHEMBL6746784 SCHEMBL6746784 0.51 3/20
SCHEMBL10733330 SCHEMBL10733330 0.49 3/20
SCHEMBL13100599 SCHEMBL13100599 0.47 3/20
SCHEMBL16547155 SCHEMBL16547155 0.46 3/20
SCHEMBL27616000 SCHEMBL27616000 0.43 3/20
SCHEMBL18159313 SCHEMBL18159313 0.43 3/20
SCHEMBL14129688 SCHEMBL14129688 0.42 3/20
SCHEMBL27615933 SCHEMBL27615933 0.42 3/20
SCHEMBL5467997 SCHEMBL5467997 0.41 3/20

Clinical trials — most relevant to FGF23 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Role of Vitamin K2 in Chronic Kidney Disease PHASE4RECRUITING
Role of Coenzyme Q10 in Chronic Kidney Disease PHASE4RECRUITING
Beneficial Effects of Vitamin D Combined With Oral Iron Supplementation in Patients With Chronic Heart Failure and Iron Deficiency PHASE4UNKNOWN
Effect of Etelcalcetide on Cardiac Hypertrophy in Hemodialysis Patients PHASE4COMPLETED
The Study of Efficacy and Safety of REGPARA Drug in Dialysis Patients Have High Blood Levels of Parathyroid PHASE4COMPLETED
Sevelamer and Secondary Hyperparathyroidism in Chronic Kidney Disease PHASE3COMPLETED
DePTH: De-emphasize PTH PHASE2ACTIVE_NOT_RECRUITING
Vitamin D Deficiency Treatment Outcomes After Non-ST-Segment Elevation Myocardial Infarction PHASE2UNKNOWN
Effects of Lanthanum Carbonate on FGF-23 in Subjects With Stage 3 CKD PHASE2COMPLETED
Healthy Combine Study PHASE1COMPLETED
Fibroblast Growth Factor-23 (FGF-23) is Independently Associated With Left Ventricular Mass Index (LVMI) and Myocardial Performance Index (MPI) in Haemodialysis Patients nanUNKNOWN
PAINDYS_Characterizing Pain in Fibrous Dysplasia of Bone/McCune-Albright Syndrome: an Exploratory Pilot Study nanNOT_YET_RECRUITING
Vitamin D Deficiency, Insulin Resistance and FGF-23 nanCOMPLETED
New Biomarkers in Heart- and Renal Failure nanCOMPLETED
Vitamin D Deficiency in Adolescent Girls nanCOMPLETED
Improving Phosphate Control in Children With CKD nanUNKNOWN
Fibroblast Growth Factor 23 and Sclerostin in Relation to Calcium in COVID-19 Patients nanCOMPLETED
Cardiorenal Risk Stratification Pilot Study nanUNKNOWN
Physiologic Regulation of FGF-23 nanCOMPLETED
Evaluation of Serum Klotho as a Predictor of Progression of Cardiovascular Calcification in Chronic Kidney Disease nanUNKNOWN
The Effect of REgulation of PArathyroId hoRmone in Patients With Chronic Kidney Disease to Investigate the Change in Bone Mineral Density nanRECRUITING
Phosphate Bioavailability Hormonal Response to a Breakfast Meal in Healthy Humans nanCOMPLETED
Modulation of Gut Microbiota in End-stage Renal Disease nanWITHDRAWN
Circadian Rhythm Modulation by Dietary Phosphorus in Chronic Kidney Disease nanCOMPLETED
Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment nanCOMPLETED
Cardiovascular Effects of Empagliflozine nanUNKNOWN
Different Vitamin D Preparations & FGF23 in Humans nanCOMPLETED
Markers of Metabolism and Vascular Access in ESRD nanUNKNOWN
Relationship Between Fibroblast Growth Factor 23 and Recurrence of Atrial Fibrillation After Catheter Ablation nanUNKNOWN
Fosrenol and Phosphorus Balance - Lanthanum Carbonate nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a FGF23 binder may also engage these)

ProteinNameSimilarity
Q9EPC2 — 0.987 Q9EPC2 →
Q8VI82 — 0.985 Q8VI82 →
P55075 — 0.984 P55075 →
P10767 — 0.974 P10767 →
P21658 — 0.973 P21658 →
P37237 — 0.971 P37237 →
Q9NSA1 — 0.971 Q9NSA1 →
P48802 — 0.970 P48802 →
P17491 — 0.970 P17491 →
O95750 — 0.969 O95750 →
Q04999 — 0.968 Q04999 →
P63075 — 0.968 P63075 →
Q8R4K8 — 0.968 Q8R4K8 →
Q92914 — 0.968 Q92914 →
O75129 — 0.968 O75129 →
Q9NZV5 — 0.968 Q9NZV5 →
Q9WU72 — 0.968 Q9WU72 →
Q0VCN6 — 0.968 Q0VCN6 →
Q6L9W6 — 0.967 Q6L9W6 →
P09529 — 0.967 P09529 →
P04202 — 0.967 P04202 →
Q90722 — 0.967 Q90722 →
P17246 — 0.966 P17246 →
Q9JJN1 — 0.966 Q9JJN1 →
Q6L8S8 — 0.966 Q6L8S8 →
P20722 — 0.965 P20722 →
Q9Z1Y6 — 0.965 Q9Z1Y6 →
P42917 — 0.965 P42917 →
Q16586 — 0.965 Q16586 →
Q04906 — 0.965 Q04906 →