SCHEMBL16587412

SCHEMBL16587412

CC(=O)c1ccc2c(c1)nc(C)n2Cc1c(C)cccc1C

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 7/20 0.54
▸ NPC1 O15118 6/20 0.54
▸ KMT2A Q03164 1/20 0.52
▸ KDM4E B2RXH2 2/20 0.50
▸ SMN1; SMN2 Q16637 4/20 0.47
▸ LMNA P02545 2/20 0.47
▸ RECQL P46063 1/20 0.47
▸ RPS6KA5 O75582 1/20 0.46
▸ PPARG P37231 3/20 0.45
▸ ALDH1A1 P00352 1/20 0.45
▸ SLC22A12 Q96S37 1/20 0.45
▸ MAPT P10636 2/20 0.44
▸ POLB P06746 1/20 0.44
▸ HDAC1 Q13547 1/20 0.44
▸ HDAC6 Q9UBN7 1/20 0.44
▸ GALR3 O60755 1/20 0.44
▸ NR2F2 P24468 1/20 0.44
▸ RORC P51449 1/20 0.44
▸ HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6112835 0.81 KMT2A (0.76) RAB9ANPC1KMT2AKDM4ESMN1; SMN2
SCHEMBL16587410 0.80 SLC22A12 (0.56) RAB9ANPC1SLC22A12HDAC1HDAC6
SCHEMBL16587411 0.77 KDM4E (0.56) RAB9ANPC1KDM4ELMNASLC22A12
SCHEMBL6112696 0.73 RAB9A (0.72) RAB9ANPC1KMT2AKDM4ESMN1; SMN2
SCHEMBL11976860 0.72 KDM4E (0.54) RAB9ANPC1KDM4EPPARGALDH1A1
SCHEMBL29342745 0.72 PPARG (0.55) KMT2AKDM4EPPARGALDH1A1MAPT
SCHEMBL31085038 0.72 KDM4E (0.50) RAB9ANPC1KMT2AKDM4ESMN1; SMN2
SCHEMBL31072768 0.72 PPARG (0.55) KMT2AKDM4EPPARGALDH1A1MAPT
SCHEMBL11977100 0.71 SLC22A12 (0.51) KDM4ESMN1; SMN2ALDH1A1SLC22A12POLB
SCHEMBL8039631 0.71 PPARG (0.68) PPARGALDH1A1RORCHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9359350-B2 Ring-fused compound SATO PHARMACEUTICAL CO., LTD. (JP) 2016-06-07 — — US disclosed
US-20150203490-A1 RING-FUSED COMPOUND SATO PHARMACEUTICAL CO., LTD. (JP) 2015-07-23 — — US disclosed
US-8987473-B2 Ring-fused compound SATO PHARMACEUTICAL CO., LTD. (JP) 2015-03-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150203490-A1 RING-FUSED COMPOUND URB2, RCOR1, RCC2 RAB9A 171/4885NPC1 1375/4885KMT2A 381/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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