Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16472413 | 1.00 | KCNH2 (0.40) | KCNH2GPR119NR1H2NR1H3PTGES | |
| SCHEMBL16472415 | 0.83 | GPR119 (0.45) | GPR119PTGESHRH3MAPT | |
| SCHEMBL16587742 | 0.83 | GPR119 (0.45) | GPR119PTGESHRH3MAPT | |
| SCHEMBL16587752 | 0.80 | OGA (0.38) | PTGESHRH3JAK2JAK1TYK2 | |
| SCHEMBL16472266 | 0.80 | OGA (0.38) | PTGESHRH3JAK2JAK1TYK2 | |
| SCHEMBL16587751 | 0.79 | GPR119 (0.42) | KCNH2GPR119HRH3JAK2JAK1 | |
| SCHEMBL16472271 | 0.79 | GPR119 (0.42) | KCNH2GPR119HRH3JAK2JAK1 | |
| SCHEMBL16472305 | 0.77 | GPR119 (0.40) | KCNH2GPR119PTGESHRH3JAK2 | |
| SCHEMBL12988252 | 0.75 | KCNH2 (0.48) | KCNH2GPR119NR1H2NR1H3HRH3 | |
| SCHEMBL16472342 | 0.72 | ADRB1 (0.39) | GPR119MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987268-B2 | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-24 | — | — | US | disclosed |