Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 16/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14790984 | 0.88 | CHRNB2 (0.32) | PANK3RIPK1TACR3 | |
| SCHEMBL9920484 | 0.87 | PANK3 (0.45) | PANK3RIPK1JAK2JAK1TYK2 | |
| SCHEMBL9920182 | 0.84 | PANK3 (0.44) | PANK3RIPK1JAK2JAK1TYK2 | |
| SCHEMBL16478731 | 0.83 | PANK3 (0.46) | PANK3RIPK1JAK2JAK1TYK2 | |
| SCHEMBL16478698 | 0.83 | PANK3 (0.46) | PANK3RIPK1JAK2JAK1TYK2 | |
| SCHEMBL16472337 | 0.83 | OGA (0.38) | — | |
| SCHEMBL9918308 | 0.83 | OGA (0.38) | — | |
| SCHEMBL9918330 | 0.83 | OGA (0.38) | — | |
| SCHEMBL9920467 | 0.79 | GPR119 (0.47) | PANK3JAK2JAK1TYK2JAK3 | |
| SCHEMBL9920172 | 0.79 | GPR119 (0.47) | PANK3JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987268-B2 | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-24 | — | — | US | disclosed |