Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16472505 | 0.84 | MAPT (0.47) | LMNAKMT2ARAB9AKDM4EALDH1A1 | |
| SCHEMBL13024397 | 0.80 | MAPT (0.46) | LMNAMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL12993441 | 0.76 | EPHX2 (0.59) | LMNAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL3202382 | 0.75 | LMNA (0.53) | LMNAMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL12424191 | 0.75 | NPC1 (0.40) | RAB9AALDH1A1MAPTEPHX2NR1H4 | |
| SCHEMBL21766773 | 0.75 | RORC (0.47) | MEN1KMT2AALDH1A1 | |
| SCHEMBL2133620 | 0.74 | LMNA (0.52) | LMNAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL14075263 | 0.73 | POLB (0.41) | LMNAMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL829871 | 0.73 | TSHR (0.36) | LMNARAB9AKDM4EALDH1A1POLB | |
| SCHEMBL22255134 | 0.72 | NAMPT (0.49) | LMNAMEN1KMT2ARAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987268-B2 | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-24 | — | — | US | disclosed |