Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 2/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16472453 | 0.83 | JAK1 (0.47) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL16472368 | 0.81 | NPC1 (0.39) | OGAPTGESNR1I2SMN1; SMN2NPC1 | |
| SCHEMBL18291300 | 0.81 | IKBKB (0.36) | OGAPTGESSMN1; SMN2NPC1RAB9A | |
| SCHEMBL16472287 | 0.81 | GPR119 (0.43) | MAPT | |
| SCHEMBL16472305 | 0.80 | GPR119 (0.40) | PTGESALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL16587752 | 0.77 | OGA (0.38) | OGAPTGESSMN1; SMN2NPC1RAB9A | |
| SCHEMBL16472266 | 0.77 | OGA (0.38) | OGAPTGESSMN1; SMN2NPC1RAB9A | |
| SCHEMBL16472278 | 0.75 | GPR119 (0.44) | PTGESMEN1KMT2AALDH1A1GAA | |
| SCHEMBL16587773 | 0.72 | GPR119 (0.39) | OGAJAK2JAK1TYK2JAK3 | |
| SCHEMBL20249348 | 0.70 | LCAT (0.36) | PTGESSMN1; SMN2NPC1RAB9AKLF5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987268-B2 | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-24 | — | — | US | disclosed |