Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 9/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291190 | 0.85 | EGFR (0.37) | LMNAHTTNPC1RAB9AKLF5 | |
| SCHEMBL20038277 | 0.85 | OGA (0.36) | IKBKBLMNAHTTPTGESNPC1 | |
| SCHEMBL16472368 | 0.84 | NPC1 (0.39) | LMNAHTTPTGESNPC1RAB9A | |
| SCHEMBL20249348 | 0.82 | LCAT (0.36) | IKBKBLMNAHTTPTGESNPC1 | |
| SCHEMBL16472266 | 0.81 | OGA (0.38) | LMNAHTTPTGESNPC1RAB9A | |
| SCHEMBL16587752 | 0.81 | OGA (0.38) | LMNAHTTPTGESNPC1RAB9A | |
| SCHEMBL16587775 | 0.81 | OGA (0.33) | LMNAHTTPTGESNPC1RAB9A | |
| SCHEMBL9413153 | 0.78 | HTT (0.44) | LMNAHTTNPC1RAB9AKLF5 | |
| Ethane SCHEMBL5093868 | 0.77 | HTT (0.43) | LMNAHTTNPC1RAB9AKLF5 | |
| SCHEMBL12595494 | 0.76 | GLS (0.40) | LMNAHTTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016194831-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | 帝人ファーマ株式会社 | 2016-12-08 | — | — | WO | disclosed |