Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 15/20 | 0.38 |
| ▸ | PIM1 | P11309 | 11/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 11/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | BRS3 | P32247 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16588195 | 0.91 | GPR119 (0.38) | EIF2AK4PIM2PIM1PIM3GPR119 | |
| SCHEMBL16588194 | 0.89 | PIM2 (0.41) | EIF2AK4PIM2PIM1PIM3 | |
| SCHEMBL18430031 | 0.86 | EIF2AK4 (0.36) | EIF2AK4PIM2PIM1PIM3BRS3 | |
| SCHEMBL15535236 | 0.86 | EIF2AK4 (0.36) | EIF2AK4PIM2PIM1PIM3BRS3 | |
| SCHEMBL15873372 | 0.86 | PIM2 (0.37) | EIF2AK4PIM2PIM1PIM3BRS3 | |
| SCHEMBL18949917 | 0.83 | EIF2AK4 (0.35) | EIF2AK4PIM2PIM1PIM3BRS3 | |
| SCHEMBL17286144 | 0.80 | MAP4K4 (0.39) | EIF2AK4PIM2PIM1PIM3BRS3 | |
| SCHEMBL18941733 | 0.79 | PIM2 (0.39) | PIM2PIM1PIM3BRS3 | |
| SCHEMBL17286146 | 0.77 | PIM2 (0.45) | PIM2PIM1PIM3 | |
| SCHEMBL19522665 | 0.77 | PIM2 (0.47) | PIM2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987457-B2 | Ring-substituted N-pyridinyl amides as kinase inhibitors | NOVARTIS AG (CH) | 2015-03-24 | — | — | US | disclosed |