Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | ROS1 | P08922 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872249 | 0.80 | CDK5 (0.49) | EPHX2CDK5ROS1ACVR1LRRK2 | |
| SCHEMBL14302646 | 0.73 | PARP10 (0.38) | EPHX2CDK5ROS1ACVR1LRRK2 | |
| SCHEMBL433753 | 0.73 | PKM (0.58) | EPHX2MEN1KMT2AMMP12PKM | |
| SCHEMBL29199433 | 0.73 | PKM (0.58) | EPHX2MEN1KMT2AMMP12PKM | |
| SCHEMBL1184463 | 0.70 | MMP12 (0.47) | EPHX2CDK5ROS1ACVR1LRRK2 | |
| SCHEMBL29783299 | 0.70 | MMP12 (0.47) | EPHX2CDK5ROS1ACVR1LRRK2 | |
| SCHEMBL8363166 | 0.70 | MEN1 (0.61) | CDK5ROS1ACVR1LRRK2MEN1 | |
| SCHEMBL1025832 | 0.69 | CA9 (0.62) | EPHX2MMP12PKMALDH1A1 | |
| SCHEMBL29754317 | 0.69 | CA9 (0.62) | EPHX2MMP12PKMALDH1A1 | |
| SCHEMBL12653067 | 0.69 | AHR (0.54) | CDK5LRRK2MEN1KMT2ARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493305-B1 | 2-AMINOINDOLE COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA | GENZYME CORP (US) | 2015-03-25 | — | — | EP | disclosed |