Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.59 |
| ▸ | AXL | P30530 | 2/20 | 0.59 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | CCNK | O75909 | 3/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.41 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | CSK | P41240 | 1/20 | 0.37 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12563103 | 0.82 | PRKCI (0.54) | PRKCIAXLBRD4CCNKCDK12 | |
| SCHEMBL27869032 | 0.81 | BRD4 (0.46) | PRKCIAXLBRD4MKNK1MKNK2 | |
| SCHEMBL1566092 | 0.81 | PRKCI (0.49) | PRKCIAXLBRD4CCNKCDK12 | |
| SCHEMBL8324165 | 0.77 | PRKCI (0.67) | PRKCIAXLCCNKCDK12RPS6KA3 | |
| SCHEMBL21677833 | 0.77 | BRD4 (0.43) | PRKCIAXLBRD4TTBK1TTBK2 | |
| SCHEMBL16588526 | 0.76 | BRD4 (0.42) | PRKCIAXLBRD4CCNKCDK12 | |
| SCHEMBL18680897 | 0.75 | AXL (0.50) | PRKCIAXLBRD4MKNK1MKNK2 | |
| SCHEMBL17963822 | 0.74 | JAK2 (0.54) | PRKCIAXLBRD4TTBK1TTBK2 | |
| SCHEMBL23089249 | 0.74 | PRKCI (0.62) | PRKCIAXLCCNKCDK12MAPK1 | |
| SCHEMBL15155103 | 0.74 | PRKCI (0.62) | PRKCIAXLCCNKCDK12MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519517-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2015-03-25 | — | — | EP | disclosed |