Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 4/20 | 0.40 |
| ▸ | MAP3K20 | Q9NYL2 | 5/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.39 |
| ▸ | CSK | P41240 | 3/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.38 |
| ▸ | ABL2 | P42684 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18012903 | 0.79 | PRKCI (0.49) | AXLPRKCIULK1MAP4K2MAP4K4 | |
| SCHEMBL27869032 | 0.79 | BRD4 (0.46) | BRD4AXLPRKCIMAP4K2MAP4K4 | |
| SCHEMBL16588527 | 0.77 | PRKCI (0.59) | BRD4AXLPRKCIMAP3K20MAPK14 | |
| SCHEMBL12563103 | 0.77 | PRKCI (0.54) | BRD4AXLPRKCIRPS6KA3TTBK1 | |
| SCHEMBL24656163 | 0.76 | PRKCI (0.42) | AXLPRKCIULK1JAK1TTBK1 | |
| SCHEMBL1566092 | 0.76 | PRKCI (0.49) | BRD4AXLPRKCIRPS6KA3TTBK1 | |
| SCHEMBL21893423 | 0.76 | ULK1 (0.47) | AXLPRKCIULK1JAK1TTBK1 | |
| SCHEMBL30543159 | 0.76 | PRKCI (0.57) | AXLPRKCIULK1JAK1TTBK1 | |
| SCHEMBL21855819 | 0.76 | PRKCI (0.41) | AXLPRKCIULK1JAK1TTBK1 | |
| SCHEMBL1467223 | 0.76 | PRKCI (0.57) | AXLPRKCIULK1JAK1TTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10544149-B2 | Bicyclic alkyne derivatives and uses thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2020-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544149-B2 | Bicyclic alkyne derivatives and uses thereof | MAPKAPK2, MAP4K2, MKNK2 | BRD4 571/4885AXL 3341/4885PRKCI 434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.