Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.41 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.40 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16588527 | 0.81 | PRKCI (0.59) | BRD4AXLPRKCIRPS6KA3NUDT1 | |
| SCHEMBL12563103 | 0.81 | PRKCI (0.54) | BRD4AXLPRKCIRPS6KA3TTBK1 | |
| SCHEMBL27939133 | 0.80 | AXL (0.40) | AXLPRKCIRPS6KA3NUDT1TRPA1 | |
| SCHEMBL1566092 | 0.79 | PRKCI (0.49) | BRD4AXLPRKCIRPS6KA3TTBK1 | |
| SCHEMBL21677833 | 0.79 | BRD4 (0.43) | BRD4AXLPRKCIRPS6KA3TTBK1 | |
| SCHEMBL16548436 | 0.77 | PRKCI (0.53) | AXLPRKCIRPS6KA3NUDT1TRPA1 | |
| SCHEMBL15154891 | 0.76 | KDR (0.47) | BRD4AXLPRKCINUDT1TRPA1 | |
| SCHEMBL29660498 | 0.76 | NUDT1 (0.50) | AXLPRKCIRPS6KA3NUDT1TRPA1 | |
| SCHEMBL1467759 | 0.76 | NUDT1 (0.50) | AXLPRKCIRPS6KA3NUDT1TRPA1 | |
| SCHEMBL16588526 | 0.74 | BRD4 (0.42) | BRD4AXLPRKCINUDT1TTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459267-A | Dihydropyrrolonaphtyridinone compounds as inhibitors of jak | TAKEDA PHARMACEUTICAL | 2012-05-16 | — | — | CN | disclosed |