Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Voriconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 17/20 | 0.91 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.91 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.91 |
| ▸ | LMNA | P02545 | 2/20 | 0.91 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.91 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.91 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.91 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.91 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.91 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.91 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Voriconazole SCHEMBL28314862 | 1.00 | CYP3A4 (0.91) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| Voriconazole SCHEMBL27920423 | 0.99 | CYP3A4 (0.89) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| Voriconazole SCHEMBL17938274 | 0.99 | CYP3A4 (0.89) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| Voriconazole SCHEMBL17938263 | 0.98 | CYP3A4 (0.88) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| Voriconazole SCHEMBL29378592 | 0.95 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| Voriconazole SCHEMBL824156 | 0.95 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| Voriconazole SCHEMBL29449336 | 0.95 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| Voriconazole SCHEMBL1554444 | 0.95 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| Voriconazole SCHEMBL371715 | 0.95 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 | |
| Voriconazole SCHEMBL28720611 | 0.95 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2C19LMNACYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105699498-B | HPLC method for separating and analyzing voriconazole phosphate or related substances of pharmaceutical salts of voriconazole phosphate | 陕西合成药业股份有限公司 | 2020-06-12 | — | — | CN | claimed |
| CN-103304600-B | A kind of voriconazole phosphate ester trihydrate and its preparation method and application | 陕西合成药业股份有限公司 | 2018-05-25 | — | — | CN | claimed |
| CN-113004328-A | Voriconazole phosphocholine inner salt intermediate, preparation method and method for preparing voriconazole phosphocholine inner salt | 重庆西米瑞医药技术有限公司 | 2021-06-22 | — | — | CN | disclosed |
| CN-112979704-A | Voriconazole phosphocholine inner salt key intermediate and preparation method thereof | 重庆西米瑞医药技术有限公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-105699498-B | HPLC method for separating and analyzing voriconazole phosphate or related substances of pharmaceutical salts of voriconazole phosphate | 陕西合成药业股份有限公司 | 2020-06-12 | — | — | CN | disclosed |
| CN-105699498-B | HPLC method for separating and analyzing voriconazole phosphate or related substances of pharmaceutical salts of voriconazole phosphate | 陕西合成药业股份有限公司 | 2020-06-12 | — | — | CN | disclosed |
| CN-104844579-B | Method for preparing voriconazole crystal form I | 中国医学科学院药物研究所 | 2020-01-24 | — | — | CN | disclosed |
| CN-104211731-B | Method for preparing high-purity voriconazole phosphate | 陕西合成药业股份有限公司 | 2017-05-17 | — | — | CN | disclosed |
| CN-104211731-B | Method for preparing high-purity voriconazole phosphate | 陕西合成药业股份有限公司 | 2017-05-17 | — | — | CN | disclosed |
| CN-104211731-B | Method for preparing high-purity voriconazole phosphate | 陕西合成药业股份有限公司 | 2017-05-17 | — | — | CN | disclosed |
| US-9650400-B2 | Voriconazole sodium phosphate hydrates and polymorphs thereof | SHAANXI SYNTHETIC PHARMACEUTICAL CO., LTD. (CN) | 2017-05-16 | — | — | US | disclosed |
| US-20160215008-A1 | VORICONAZOLE SODIUM PHOSPHATE HYDRATES AND POLYMORPHS THEREOF | SHAANXI SYNTHETIC PHARMACEUTICAL CO., LTD. (CN) | 2016-07-28 | — | — | US | disclosed |
| US-20160215008-A1 | VORICONAZOLE SODIUM PHOSPHATE HYDRATES AND POLYMORPHS THEREOF | SHAANXI SYNTHETIC PHARMACEUTICAL CO., LTD. (CN) | 2016-07-28 | — | — | US | disclosed |
| CN-105699498-A | HPLC method for separating and analyzing voriconazole prodrug related substances | 陕西合成药业股份有限公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-105277629-A | HPLC method for separating and analyzing voriconazole phosphate or pharmaceutical salt isomer thereof | Shaanxi synthetic pharmaceutical co ltd | 2016-01-27 | — | — | CN | disclosed |
| CN-105277629-A | HPLC method for separating and analyzing voriconazole phosphate or pharmaceutical salt isomer thereof | Shaanxi synthetic pharmaceutical co ltd | 2016-01-27 | — | — | CN | disclosed |
| CN-105277629-A | HPLC method for separating and analyzing voriconazole phosphate or pharmaceutical salt isomer thereof | Shaanxi synthetic pharmaceutical co ltd | 2016-01-27 | — | — | CN | disclosed |
| WO-2015043453-A1 | VORICONAZOLE SODIUM PHOSPHATE HYDRATES AND POLYMORPHS THEREOF | 陕西合成药业股份有限公司 | 2015-04-02 | — | — | WO | disclosed |
| CN-104211731-A | Method for preparing high-purity voriconazole phosphate | SHAANXI HECHENG MEDICINE CO LTD | 2014-12-17 | — | — | CN | disclosed |
| CN-104211731-A | Method for preparing high-purity voriconazole phosphate | SHAANXI HECHENG MEDICINE CO LTD | 2014-12-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160215008-A1 | VORICONAZOLE SODIUM PHOSPHATE HYDRATES AND POLYMORPHS THEREOF | PIK3C3, WNK3, ERG28 | CYP3A4 51/4885CYP2C9 202/4885CYP2C19 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.