Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5481920 | 0.92 | TDP1 (0.62) | TDP1ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL24304923 | 0.78 | APP (0.57) | TDP1ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL1667359 | 0.78 | TDP1 (0.76) | TDP1ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL1990800 | 0.77 | TDP1 (0.57) | TDP1CARM1PRMT6DRD2DRD4 | |
| SCHEMBL1278162 | 0.77 | TDP1 (0.53) | TDP1CARM1PRMT6DRD2DRD4 | |
| SCHEMBL10533845 | 0.74 | PARP15 (0.56) | TDP1CARM1PRMT6 | |
| SCHEMBL17028904 | 0.74 | TDP1 (1.00) | TDP1ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL1583161 | 0.74 | TDP1 (1.00) | TDP1ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL1582872 | 0.74 | TDP1 (1.00) | TDP1ALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL31220 | 0.74 | TDP1 (1.00) | TDP1ALDH1A1TP53CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365819-B1 | PHARMACOPHORES, COMPOUNDS AND METHODS HAVING APPLICATION IN THE TREATMENT OF CANCER THROUGH INHIBITION OF CYP17A1 AND CYP19A1 | MANGOSUTHU UNIV OF TECHNOLOGY (ZA) | 2023-06-07 | — | — | EP | disclosed |
| EP-3049084-A4 | NOVEL FUNCTIONALIZED 5-(PHENOXYMETHYL)-1,3-DIOXANE ANALOGS EXHIBITNG CYTOCHROME P450 INHIBITION | Cortendo AB (publ) (US) | 2017-03-15 | — | — | EP | disclosed |
| US-20160244436-A1 | NOVEL FUNCTIONALIZED 5-(PHENOXYMETHYL)-1,3-DIOXANE ANALOGS EXHIBITING CYTOCHROME P450 INHIBITION AND THEIR METHOD OF USE | CORTENDO AB (PUBL) | 2016-08-25 | — | — | US | disclosed |
| US-20160244436-A1 | NOVEL FUNCTIONALIZED 5-(PHENOXYMETHYL)-1,3-DIOXANE ANALOGS EXHIBITING CYTOCHROME P450 INHIBITION AND THEIR METHOD OF USE | CORTENDO AB (PUBL) | 2016-08-25 | — | — | US | disclosed |
| EP-3049084-A1 | NOVEL FUNCTIONALIZED 5-(PHENOXYMETHYL)-1,3-DIOXANE ANALOGS EXHIBITNG CYTOCHROME P450 INHIBITION | Cortendo AB (publ) (US) | 2016-08-03 | — | — | EP | disclosed |
| EP-3049084-A1 | NOVEL FUNCTIONALIZED 5-(PHENOXYMETHYL)-1,3-DIOXANE ANALOGS EXHIBITNG CYTOCHROME P450 INHIBITION | Cortendo AB (publ) (US) | 2016-08-03 | — | — | EP | disclosed |
| CN-105764512-A | Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition | 科尔泰多公众股份公司 | 2016-07-13 | — | — | CN | disclosed |
| CN-105764512-A | Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition | 科尔泰多公众股份公司 | 2016-07-13 | — | — | CN | disclosed |
| WO-2015048311-A1 | NOVEL FUNCTIONALIZED 5-(PHENOXYMETHYL)-1,3-DIOXANE ANALOGS EXHIBITNG CYTOCHROME P450 INHIBITION | CORTENDO AB (PUBL) (US) | 2015-04-02 | — | — | WO | disclosed |
| WO-2015048311-A1 | NOVEL FUNCTIONALIZED 5-(PHENOXYMETHYL)-1,3-DIOXANE ANALOGS EXHIBITNG CYTOCHROME P450 INHIBITION | CORTENDO AB (PUBL) (US) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160244436-A1 | NOVEL FUNCTIONALIZED 5-(PHENOXYMETHYL)-1,3-DIOXANE ANALOGS EXHIBITING CYTOCHROME P450 INHIBITION AND THEIR METHOD OF USE | CYP11B1, CYP11B2, CYP21A2 | TDP1 964/4885ALDH1A1 1008/4885TP53 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.