Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.68 |
| ▸ | SNCA | P37840 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16596373 | 0.90 | ENPP2 (0.56) | APPSNCAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16596318 | 0.89 | APP (0.72) | APPSNCAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL17958368 | 0.89 | APP (0.72) | APPSNCAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL17971235 | 0.88 | APP (0.71) | APPSNCAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16596372 | 0.85 | ENPP2 (0.49) | APPSNCAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16596380 | 0.85 | ENPP2 (0.51) | APPSNCAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16596381 | 0.84 | ENPP2 (0.51) | APPSNCAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16596428 | 0.84 | ENPP2 (0.50) | APPSNCAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16596271 | 0.83 | ENPP2 (0.49) | APPSNCAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16596375 | 0.81 | APP (0.64) | APPSNCAALDH1A1SMN1; SMN2ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015042053-A1 | VINYL AUTOTAXIN INHIBITOR COMPOUNDS | PHARMAKEA, INC. (US) | 2015-03-26 | — | — | WO | disclosed |
| US-8952016-B2 | Substituted xanthine derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2015-02-10 | — | — | US | disclosed |