Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.64 |
| ▸ | SNCA | P37840 | 6/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19156289 | 0.92 | ENPP2 (0.56) | APPSNCAENPP2PTGDR2MAPT | |
| SCHEMBL17958325 | 0.90 | APP (0.66) | APPSNCAENPP2PTGDR2ALDH1A1 | |
| SCHEMBL16587066 | 0.90 | APP (0.66) | APPSNCAENPP2PTGDR2ALDH1A1 | |
| SCHEMBL16596307 | 0.90 | APP (0.51) | APPSNCAENPP2PTGDR2ALDH1A1 | |
| SCHEMBL17971216 | 0.88 | APP (0.66) | APPSNCAENPP2PTGDR2ALDH1A1 | |
| SCHEMBL16596376 | 0.87 | ENPP2 (0.56) | APPSNCAENPP2PTGDR2ALDH1A1 | |
| SCHEMBL16596423 | 0.86 | APP (0.46) | APPSNCAENPP2PTGDR2ALDH1A1 | |
| SCHEMBL17958313 | 0.84 | APP (0.64) | APPSNCAENPP2PTGDR2ALDH1A1 | |
| SCHEMBL16587073 | 0.84 | APP (0.64) | APPSNCAENPP2PTGDR2ALDH1A1 | |
| SCHEMBL16596426 | 0.84 | APP (0.43) | APPENPP2PTGDR2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015042053-A1 | VINYL AUTOTAXIN INHIBITOR COMPOUNDS | PHARMAKEA, INC. (US) | 2015-03-26 | — | — | WO | disclosed |
| US-8952016-B2 | Substituted xanthine derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2015-02-10 | — | — | US | disclosed |