Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16596426 | 0.95 | APP (0.43) | APPPTGDR2MAPTLMNASMN1; SMN2 | |
| SCHEMBL17958327 | 0.91 | APP (0.53) | APPPTGDR2MAPTLMNASMN1; SMN2 | |
| SCHEMBL16596241 | 0.91 | APP (0.53) | APPPTGDR2MAPTLMNASMN1; SMN2 | |
| SCHEMBL16596375 | 0.90 | APP (0.64) | APPPTGDR2MAPTLMNASMN1; SMN2 | |
| SCHEMBL17971219 | 0.89 | MAPT (0.53) | APPPTGDR2MAPTLMNASMN1; SMN2 | |
| SCHEMBL16596257 | 0.86 | ENPP2 (0.51) | APPPTGDR2MAPTLMNASMN1; SMN2 | |
| SCHEMBL17971223 | 0.83 | MAPT (0.50) | APPPTGDR2MAPTLMNASMN1; SMN2 | |
| SCHEMBL17958356 | 0.83 | ENPP2 (0.59) | APPPTGDR2MAPTENPP2SNCA | |
| SCHEMBL17958357 | 0.83 | ENPP2 (0.59) | APPPTGDR2MAPTENPP2SNCA | |
| SCHEMBL19156289 | 0.83 | ENPP2 (0.56) | APPPTGDR2MAPTSMN1; SMN2ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015042053-A1 | VINYL AUTOTAXIN INHIBITOR COMPOUNDS | PHARMAKEA, INC. (US) | 2015-03-26 | — | — | WO | disclosed |