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SCHEMBL16598017

SCHEMBL16598017

O=C1c2ccccc2C(=O)N1c1ccc(Oc2cccc(Oc3ccc(N4C(=O)c5cccc(-c6ccc7c(c6)C(=O)N(c6ccc(Oc8cccc(N9C(=O)c%10cccc(-c%11ccc%12c(c%11)C(=O)N(c%11ccc(Oc%13cccc(N%14C(=O)c%15ccccc%15C%14=O)c%13)cc%11)C%12=O)c%10C9=O)c8)cc6)C7=O)c5C4=O)cc3)c2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 1/20 0.58
▸ KMT2A Q03164 6/20 0.47
▸ MEN1 O00255 4/20 0.47
▸ POLB P06746 1/20 0.47
▸ MAPK1 P28482 1/20 0.47
▸ LPAR1 Q92633 1/20 0.47
▸ LPAR5 Q9H1C0 1/20 0.47
▸ LPAR3 Q9UBY5 1/20 0.47
▸ ALDH1A1 P00352 2/20 0.45
▸ MAPT P10636 1/20 0.45
▸ GRM5 P41594 1/20 0.44
▸ HTT P42858 1/20 0.44
▸ HSPA1A P0DMV8 1/20 0.44
▸ PABPC1 P11940 1/20 0.44
▸ HPGD P15428 2/20 0.43
▸ PTGES O14684 1/20 0.42
▸ MCHR1 Q99705 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.42
▸ ADORA2A P29274 1/20 0.41
▸ NR1H2 P55055 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16597893 0.99 BRD4 (0.56) BRD4KMT2AMEN1POLBMAPK1
SCHEMBL17938180 0.90 BRD4 (0.48) BRD4KMT2AMEN1POLBMAPK1
SCHEMBL16598458 0.88 BRD4 (0.46) BRD4KMT2AMEN1POLBMAPK1
SCHEMBL21082655 0.87 BRD4 (0.50) BRD4KMT2AMEN1POLBMAPK1
SCHEMBL19689370 0.86 BRD4 (0.72) BRD4KMT2AMEN1POLBMAPK1
SCHEMBL10709583 0.84 BRD4 (0.64) BRD4KMT2AMEN1POLBMAPK1
SCHEMBL13253262 0.84 ADORA2A (0.51) BRD4KMT2AMEN1ALDH1A1MAPT
SCHEMBL8429600 0.83 GRM5 (0.56) BRD4KMT2AMEN1POLBMAPK1
SCHEMBL21090951 0.83 BRD4 (0.40) BRD4KMT2AMEN1POLBMAPK1
SCHEMBL17281688 0.82 BRD4 (0.61) BRD4KMT2AMEN1POLBMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3049459-A1 AROMATIC POLYIMIDES SUITABLE FOR 3D PRINTING PROCESSES PolyOne Corporation (US) 2016-08-03 — — EP claimed
WO-2015048071-A1 AROMATIC POLYIMIDES SUITABLE FOR 3D PRINTING PROCESSES POLYONE CORPORATION (US) 2015-04-02 — — WO claimed
US-20190177484-A1 AROMATIC POLYIMIDES SUITABLE FOR 3D PRINTING PROCESSES POLYONE CORPORATION (US) 2019-06-13 — — US disclosed
US-10240000-B2 Aromatic polyimides suitable for 3D printing processes POLYONE CORPORATION (US) 2019-03-26 — — US disclosed
EP-3049459-A1 AROMATIC POLYIMIDES SUITABLE FOR 3D PRINTING PROCESSES PolyOne Corporation (US) 2016-08-03 — — EP disclosed
US-20160215096-A1 PREPARATION OF IMIDE OLIGOMERS VIA CONCURRENT REACTIVE EXTRUSION POLYONE CORPORATION (US) 2016-07-28 — — US disclosed
US-20160215096-A1 PREPARATION OF IMIDE OLIGOMERS VIA CONCURRENT REACTIVE EXTRUSION POLYONE CORPORATION (US) 2016-07-28 — — US disclosed
WO-2015048071-A1 AROMATIC POLYIMIDES SUITABLE FOR 3D PRINTING PROCESSES POLYONE CORPORATION (US) 2015-04-02 — — WO disclosed