SCHEMBL10709583

SCHEMBL10709583

O=C1c2ccccc2C(=O)N1c1ccc(Oc2cccc(N3C(=O)c4ccccc4C3=O)c2)cc1

nearest known ligand 0.64

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.64
GRM5 P41594 1/20 0.57
KMT2A Q03164 8/20 0.55
MEN1 O00255 7/20 0.53
POLB P06746 1/20 0.53
MAPK1 P28482 1/20 0.53
MGLL Q99685 1/20 0.53
NR1H3 Q13133 4/20 0.52
NR1H2 P55055 2/20 0.52
LPAR1 Q92633 1/20 0.52
LPAR5 Q9H1C0 1/20 0.52
LPAR3 Q9UBY5 1/20 0.52
SCN2A Q99250 1/20 0.50
ALDH1A1 P00352 1/20 0.50
MAPT P10636 1/20 0.50
HTT P42858 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19689370 0.95 BRD4 (0.72) BRD4GRM5KMT2AMEN1POLB
SCHEMBL8429600 0.92 GRM5 (0.56) BRD4GRM5KMT2AMEN1POLB
SCHEMBL13302880 0.90 MGLL (0.65) BRD4GRM5KMT2AMEN1MGLL
SCHEMBL3408445 0.89 KMT2A (0.66) BRD4KMT2AMEN1MGLLNR1H3
SCHEMBL20346175 0.89 BRD4 (0.63) BRD4GRM5KMT2AMEN1POLB
SCHEMBL10641093 0.87 BRD4 (0.65) BRD4GRM5KMT2AMEN1POLB
SCHEMBL17272758 0.87 BRD4 (0.73) BRD4KMT2AMEN1POLBMAPK1
SCHEMBL16597893 0.85 BRD4 (0.56) BRD4GRM5KMT2AMEN1POLB
SCHEMBL16598017 0.84 BRD4 (0.58) BRD4GRM5KMT2AMEN1POLB
SCHEMBL21107869 0.83 KMT2A (0.63) BRD4KMT2AMEN1MGLLNR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4517315-A Production of a film-like or fibrous structure of an aromatic polyester TEIJIN LIMITED (JP) 1985-05-14 US claimed
EP-0156966-B1 WHOLLY AROMATIC POLYESTER COMPOSITION AND PROCESS FOR PRODUCING IT TEIJIN LIMITED (JP) 1988-10-19 EP disclosed
EP-0070539-B1 PROCESS FOR PRODUCING A FILM-LIKE AND FIBROUS ARTICLE OF A WHOLLY AROMATIC POLYESTER TEIJIN LIMITED (JP) 1987-07-01 EP disclosed
EP-0091669-B1 PROCESS FOR PRODUCING POROUS, FILM-LIKE OR FIBROUS STRUCTURE OF AROMATIC POLYESTER TEIJIN LIMITED (JP) 1986-10-01 EP disclosed
EP-0057387-B1 PRODUCTION OF A FILM-LIKE OR FIBROUS STRUCTURE OF AN AROMATIC POLYESTER TEIJIN LIMITED (JP) 1986-05-07 EP disclosed
EP-0156966-A1 Wholly aromatic polyester composition and process for producing it TEIJIN LIMITED (JP) 1985-10-09 EP disclosed
US-4517315-A Production of a film-like or fibrous structure of an aromatic polyester TEIJIN LIMITED (JP) 1985-05-14 US disclosed
US-4419308-A SOLVENT EXTRACTION OF IMIDE OR ISOCYANURATE TEIJIN LIMITED (JP) 1983-12-06 US disclosed
US-4416839-A Wholly aromatic polyester composition, process for production thereof, and production therefrom of a film-like or fibrous article of a wholly aromatic polyester TEIJIN LIMITED (JP) 1983-11-22 US disclosed
EP-0091669-A2 Process for producing porous, film-like or fibrous structure of aromatic polyester TEIJIN LIMITED (JP) 1983-10-19 EP disclosed
EP-0070539-A1 Process for producing a film-like and fibrous article of a wholly aromatic polyester TEIJIN LIMITED (JP) 1983-01-26 EP disclosed
EP-0057387-A2 Production of a film-like or fibrous structure of an aromatic polyester TEIJIN LIMITED (JP) 1982-08-11 EP disclosed