Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.62 |
| ▸ | LMNA | P02545 | 11/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.61 |
| ▸ | MEN1 | O00255 | 8/20 | 0.61 |
| ▸ | HTT | P42858 | 7/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | TEX264 | Q9Y6I9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659816 | 1.00 | MAPT (0.62) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL22337232 | 0.85 | KMT2A (0.83) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL1657376 | 0.83 | MAPT (0.66) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL13100734 | 0.83 | MAPT (0.62) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL1657372 | 0.83 | MAPT (0.66) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL1660585 | 0.82 | LMNA (0.68) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL1660591 | 0.82 | LMNA (0.68) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL11899415 | 0.82 | MAPT (0.64) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL11899414 | 0.82 | MAPT (0.64) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL22737807 | 0.82 | MAPT (0.68) | MAPTLMNAKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202814-A1 | COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DI SIENA (IT) | 2012-08-09 | — | — | US | disclosed |
| US-20120202814-A1 | COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DI SIENA (IT) | 2012-08-09 | — | — | US | disclosed |
| US-20120202814-A1 | COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DI SIENA (IT) | 2012-08-09 | — | — | US | disclosed |
| WO-2011039735-A2 | COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2011-04-07 | — | — | WO | disclosed |
| WO-2011039735-A2 | COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202814-A1 | COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF | DDX3X, DDX21, DDX39B | MAPT 4074/4885LMNA 1640/4885KMT2A 2610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.