Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | GPR183 | P32249 | 8/20 | 0.64 |
| ▸ | CCR2 | P41597 | 3/20 | 0.50 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.50 |
| ▸ | ITGAL | P20701 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16598979 | 1.00 | NPC1 (0.66) | NPC1RAB9ATDP1GPR183CCR2 | |
| SCHEMBL4519049 | 0.81 | NPC1 (0.73) | NPC1RAB9ATDP1GPR183CCR2 | |
| SCHEMBL4519044 | 0.81 | NPC1 (0.73) | NPC1RAB9ATDP1GPR183CCR2 | |
| SCHEMBL16614487 | 0.81 | GPR183 (0.77) | NPC1RAB9ATDP1GPR183 | |
| SCHEMBL4559427 | 0.80 | NPC1 (0.67) | NPC1RAB9ATDP1GPR183CCR2 | |
| SCHEMBL4559426 | 0.80 | NPC1 (0.67) | NPC1RAB9ATDP1GPR183CCR2 | |
| SCHEMBL10459440 | 0.80 | RAB9A (1.00) | NPC1RAB9ATDP1GPR183ITGB2 | |
| SCHEMBL16599159 | 0.80 | GPR183 (0.65) | NPC1RAB9AGPR183MAPTSMN1; SMN2 | |
| SCHEMBL17954203 | 0.80 | MAPT (0.71) | NPC1RAB9AGPR183MAPTSMN1; SMN2 | |
| SCHEMBL10459439 | 0.80 | RAB9A (1.00) | NPC1RAB9ATDP1GPR183ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776979-B2 | EBI2 modulators | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2017-10-03 | — | — | US | disclosed |
| US-9776979-B2 | EBI2 modulators | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160214951-A1 | EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2016-07-28 | — | — | US | disclosed |
| US-20160214951-A1 | EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2016-07-28 | — | — | US | disclosed |
| WO-2015048570-A2 | EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |
| WO-2015048570-A2 | EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214951-A1 | EBI2 MODULATORS | BIRC2, HAVCR2, MAVS | NPC1 2095/4885RAB9A 1970/4885TDP1 3593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.