Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10001178 | 0.81 | POLB (0.60) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL31137907 | 0.78 | POLB (0.67) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL578591 | 0.78 | POLB (0.67) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL2560056 | 0.77 | CES1 (0.48) | — | |
| SCHEMBL22569116 | 0.77 | HTT (0.78) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL23181527 | 0.77 | HCAR2 (0.41) | POLBHCAR2 | |
| SCHEMBL7974908 | 0.77 | HCAR2 (0.60) | HCAR2SMYD3 | |
| SCHEMBL3473330 | 0.77 | HCAR2 (0.60) | HCAR2HTTRAB9ASMYD3 | |
| SCHEMBL24198782 | 0.77 | POLB (0.55) | POLBHCAR2KDM4EHTTALOX15 | |
| Hydrochloric Acid SCHEMBL31575651 | 0.76 | POLB (0.64) | POLBHCAR2KDM4EHTTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3412668-B1 | A SELECTIVE INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE-GAMMA | VERTEX PHARMA (US) | 2020-02-05 | — | — | EP | disclosed |
| US-10301304-B2 | Selective inhibitor of phosphatidylinositol 3-kinase-gamma | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-05-28 | — | — | US | disclosed |
| EP-3412668-A2 | A SELECTIVE INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE-GAMMA | Vertex Pharmaceuticals Incorporated (US) | 2018-12-12 | — | — | EP | disclosed |
| EP-3049415-B1 | A SELECTIVE INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE-GAMMA | VERTEX PHARMA (US) | 2018-07-04 | — | — | EP | disclosed |
| EP-3049415-A1 | A SELECTIVE INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE-GAMMA | Vertex Pharmaceuticals Inc. (US) | 2016-08-03 | — | — | EP | disclosed |
| US-20160214980-A1 | SELECTIVE INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE-GAMMA | VERTEX PHARMACEUTICALS INCORPORATED | 2016-07-28 | — | — | US | disclosed |
| US-20160214980-A1 | SELECTIVE INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE-GAMMA | VERTEX PHARMACEUTICALS INCORPORATED | 2016-07-28 | — | — | US | disclosed |
| WO-2015048318-A1 | A SELECTIVE INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE-GAMMA | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10301304-B2 | Selective inhibitor of phosphatidylinositol 3-kinase-gamma | PIK3CA, PIK3CG, PIK3CD | POLB 1235/4885HCAR2 4223/4885KDM4E 1682/4885 |
| US-20160214980-A1 | SELECTIVE INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE-GAMMA | PIK3CA, PIK3CG, PIK3CD | POLB 1235/4885HCAR2 4223/4885KDM4E 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.