SCHEMBL578591

SCHEMBL578591

NC(=O)c1cncc(Br)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.67
HCAR2 Q8TDS4 1/20 0.67
KDM4E B2RXH2 1/20 0.63
HTT P42858 4/20 0.56
ALOX15 P16050 1/20 0.56
RAB9A P51151 2/20 0.53
SMN1; SMN2 Q16637 3/20 0.50
PARP1 P09874 1/20 0.50
ROCK2 O75116 1/20 0.50
ALDH1A1 P00352 1/20 0.50
GAA P10253 1/20 0.50
ALOX12 P18054 1/20 0.50
ROCK1 Q13464 1/20 0.50
MAPT P10636 1/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
SMYD3 Q9H7B4 1/20 0.49
EGFR P00533 2/20 0.46
F7 P08709 1/20 0.45
F3 P13726 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31137907 1.00 POLB (0.67) POLBHCAR2KDM4EHTTALOX15
Hydrochloric Acid SCHEMBL31575651 0.98 POLB (0.64) POLBHCAR2KDM4EHTTALOX15
SCHEMBL6656331 0.85 POLB (0.50) POLBHCAR2KDM4EHTTALOX15
SCHEMBL2841794 0.84 SIRT2 (0.54) HCAR2KDM4EALDH1A1MEN1KMT2A
SCHEMBL22569116 0.82 HTT (0.78) POLBHCAR2KDM4EHTTALOX15
SCHEMBL29603529 0.80 HCAR2 (1.00) POLBHCAR2KDM4EHTTALOX15
SCHEMBL28801075 0.80 POLB (0.69) POLBHCAR2KDM4EHTTALOX15
SCHEMBL112388 0.80 HCAR2 (1.00) POLBHCAR2KDM4EHTTALOX15
SCHEMBL6652760 0.78 POLB (0.55) POLBHCAR2KDM4EHTTALOX15
SCHEMBL10500665 0.78 HCAR2 (0.96) POLBHCAR2KDM4EHTTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 383 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117143000-A Production process for improving quality of N-methylpyrrolidone 赣州中能实业有限公司 2023-12-01 CN claimed
CN-113248367-B Method for realizing continuous production of acyl chloride compound by catalysis of immobilized organic base 东南大学 2022-04-26 CN claimed
CN-113248367-A Method for realizing continuous production of acyl chloride compound by catalysis of immobilized organic base 东南大学 2021-08-13 CN claimed
CN-104262246-B A kind of 5-phenyl nicotinamide Bcr-Abl inhibitor and its preparation method and application Xi''an Jiao Tong University (CN) 2017-01-04 CN claimed
CN-104262246-A 5-phenylnicotinamide Bcr-Abl inhibitors as well as preparation method and application thereof UNIV XI AN JIAOTONG 2015-01-07 CN claimed
EP-4747247-A1 NOVEL FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF Apogee Pharmaceuticals, Inc. (CA) 2026-05-27 EP disclosed
US-20260008783-A1 MODULATORS OF FSHR AND USES THEREOF GEDEON RICHTER PLC (HU) 2026-01-08 US disclosed
US-12410137-B2 Fatty acid amide hydrolase modulators, compositions comprising the same and uses thereof APOGEE PHARMACEUTICALS, INC. (CA) 2025-09-09 US disclosed
EP-4577206-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF Celmatix Inc. (US) 2025-07-02 EP disclosed
US-20250129027-A1 FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF APOGEE PHARMACEUTICALS, INC. (CA) 2025-04-24 US disclosed
CN-115586273-B Compound non-targeting identification method based on bromine isotope labeling 遵义医科大学 2025-03-14 CN disclosed
WO-2025015420-A1 NOVEL FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF APOGEE PHARMACEUTICALS, INC. (CA) 2025-01-23 WO disclosed
US-5861423-A SIDE EFFECT REDUCTION; ADMINISTERING TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER*S AND PARKINSON*S DISEASE; ATTENTION DEFICIT DISORDER, SCHIZOPHRENIA TARGACEPT, INC., A CORPORATION OF DELAWARE 1999-01-19 US disclosed
US-5811442-A ADMINISTERING ARYL SUBSTITUTED OLEFINIC AMINE COMPOUND IN AN AMOUNT SUFFICIENT TO SELECTIVELY BIND TO AND AFFECT NICOTINIC CHOLINERGIC RECEPTOR SUBTYPES CONTAINING BETA2 SUBUNITS TARGACEPT, INC. 1998-09-22 US disclosed
WO-1998037071-A1 PHARMACEUTICAL COMPOSITIONS INCORPORATING ARYL SUBSTITUTED OLEFINIC AMINE COMPOUNDS R.J. REYNOLDS TOBACCO COMPANY (US) 1998-08-27 WO disclosed
US-5502065-A TREATING HEADACHES PFIZER INC. (US) 1996-03-26 US disclosed
WO-1995028400-A1 NOVEL BENZOFUSED 5-MEMBERED HETEROCYCLIC RINGS FOR THE TREATMENT OF MIGRAINE GLAXO GROUP LIMITED (GB) 1995-10-26 WO disclosed
WO-1993021178-A1 INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS PFIZER LIMITED (GB) 1993-10-28 WO disclosed
US-5215738-A Used for destroying hypoxic tumor cells SRI INTERNATIONAL (US) 1993-06-01 US disclosed
WO-1986006628-A1 BENZAMIDE AND NICOTINAMIDE RADIOSENSITIZERS SRI INTERNATIONAL (US) 1986-11-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008783-A1 MODULATORS OF FSHR AND USES THEREOF FSHR, GNRHR, LHCGR POLB 3698/4885HCAR2 1488/4885KDM4E 1857/4885
US-20250129027-A1 FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF FAAH, FAAH2, MGLL POLB 4023/4885HCAR2 64/4885KDM4E 1807/4885
US-12410137-B2 Fatty acid amide hydrolase modulators, compositions comprising the same and uses thereof FAAH, FAAH2, MGLL POLB 4023/4885HCAR2 64/4885KDM4E 1807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.