Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661602 | 0.87 | SCN9A (0.32) | SMN1; SMN2SCN9A | |
| SCHEMBL6902872 | 0.81 | — | — | |
| SCHEMBL6902269 | 0.78 | P2RY14 (0.33) | SCN9A | |
| SCHEMBL1659976 | 0.77 | MAP3K12 (0.34) | SCN9A | |
| SCHEMBL1660659 | 0.77 | P2RY14 (0.35) | SCN9A | |
| SCHEMBL14727808 | 0.77 | MMP2 (0.33) | SCN9A | |
| SCHEMBL6904513 | 0.76 | SCN9A (0.36) | SCN9A | |
| SCHEMBL1659926 | 0.76 | — | — | |
| SCHEMBL14717961 | 0.76 | MET (0.32) | SCN9A | |
| SCHEMBL1661829 | 0.75 | KCNN4 (0.33) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488031-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | disclosed |