Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 18/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 9/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.52 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | HTR2B | P41595 | 4/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16601159 | 1.00 | GRIN2B (0.60) | GRIN2BADRA1AGRIN1GRIN2DGRIN2A | |
| SCHEMBL16601123 | 0.83 | GRIN2B (0.62) | GRIN2BGRIN1 | |
| SCHEMBL5732849 | 0.83 | GRIN2B (0.40) | GRIN2BLMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30076104 | 0.76 | GRIN2B (0.63) | GRIN2BADRA1AGRIN1GRIN2DGRIN2A | |
| SCHEMBL16988787 | 0.75 | GRIN2B (1.00) | GRIN2BADRA1AGRIN1GRIN2DGRIN2A | |
| SCHEMBL16601001 | 0.75 | GRIN2B (1.00) | GRIN2BADRA1AGRIN1GRIN2DGRIN2A | |
| SCHEMBL16601274 | 0.75 | GRIN2B (1.00) | GRIN2BADRA1AGRIN1GRIN2DGRIN2A | |
| SCHEMBL16600800 | 0.75 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL23805564 | 0.72 | GRIN2B (0.62) | GRIN2BADRA1AGRIN1GRIN2DGRIN2A | |
| SCHEMBL23805618 | 0.72 | GRIN2B (0.62) | GRIN2BADRA1AGRIN1GRIN2DGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036221-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B | Luc Therapeutics, Inc. (US) | 2016-06-29 | — | — | EP | claimed |
| WO-2015048507-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | MNEMOSYNE PHARMACEUTICALS, INC. (US) | 2015-04-02 | — | — | WO | claimed |
| EP-3036221-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE MODULATORS OF NR2B | Luc Therapeutics, Inc. (US) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015048507-A1 | SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B | MNEMOSYNE PHARMACEUTICALS, INC. (US) | 2015-04-02 | — | — | WO | disclosed |