SCHEMBL16601650

SCHEMBL16601650

O=COc1ccc(N2C(=O)c3ccc4c5c(ccc(c35)C2=O)C(=O)N(c2ccccc2)C4=O)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.49
APAF1 O14727 1/20 0.49
KMT2A Q03164 5/20 0.47
ALDH1A1 P00352 4/20 0.47
KDM4E B2RXH2 2/20 0.47
USP2 O75604 2/20 0.47
MAPT P10636 1/20 0.47
HTT P42858 1/20 0.47
KEAP1 Q14145 1/20 0.47
NFE2L2 Q16236 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
APOBEC3A P31941 1/20 0.44
RECQL P46063 1/20 0.44
CASP6 P55212 1/20 0.44
APOBEC3G Q9HC16 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CA12 O43570 2/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16787499 0.86 POLB (0.47) POLBAPAF1KMT2AALDH1A1KDM4E
SCHEMBL12163405 0.85 CA9 (0.56) POLBAPAF1KMT2AKDM4ESMN1; SMN2
SCHEMBL18198712 0.81 POLB (0.52) POLBAPAF1KMT2AALDH1A1KDM4E
SCHEMBL31167971 0.81 POLB (0.63) POLBAPAF1KMT2AALDH1A1KDM4E
SCHEMBL7491321 0.81 POLB (0.63) POLBAPAF1KMT2AALDH1A1KDM4E
SCHEMBL17281690 0.80 MGLL (0.61) POLBAPAF1KMT2AALDH1A1KDM4E
SCHEMBL13643774 0.76 ANPEP (0.44) POLBAPAF1KMT2AALDH1A1KDM4E
SCHEMBL14164183 0.76 KMT2A (0.58) POLBKMT2AALDH1A1KDM4EMAPT
SCHEMBL16601645 0.75 POLB (0.85) POLBAPAF1KMT2AALDH1A1KDM4E
SCHEMBL23312318 0.74 PDE6D (0.63) POLBAPAF1KMT2AALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed