SCHEMBL16601666

SCHEMBL16601666

O=C1C(=O)c2ccc(-c3ccc(S)cc3)cc2-c2cc(-c3ccc(S)cc3)ccc21

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.61
APAF1 O14727 3/20 0.61
NPC1 O15118 3/20 0.61
LMNA P02545 3/20 0.61
HTT P42858 3/20 0.61
RAB9A P51151 3/20 0.61
GALK1 P51570 3/20 0.61
BLM P54132 3/20 0.61
KMT2A Q03164 3/20 0.61
SMN1; SMN2 Q16637 3/20 0.61
NPSR1 Q6W5P4 3/20 0.61
MAPT P10636 2/20 0.61
THRB P10828 2/20 0.61
PTBP1 P26599 2/20 0.61
SMAD3 P84022 2/20 0.61
XBP1 P17861 1/20 0.61
ATM Q13315 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
PTPRC P08575 11/20 0.42
PTPN1 P18031 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16601828 0.85 NPC1 (0.60) MEN1APAF1NPC1LMNAHTT
SCHEMBL28587252 0.79 MEN1 (0.91) MEN1APAF1NPC1LMNAHTT
SCHEMBL29679055 0.79 MEN1 (0.91) MEN1APAF1NPC1LMNAHTT
SCHEMBL16602010 0.78 MAPT (0.40) MEN1APAF1NPC1LMNAHTT
SCHEMBL12112513 0.77 MEN1 (0.61) MEN1APAF1NPC1LMNAHTT
SCHEMBL15383587 0.76 MEN1 (1.00) MEN1APAF1NPC1LMNAHTT
SCHEMBL30719688 0.74 NPC1 (0.83) MEN1APAF1NPC1LMNAHTT
SCHEMBL12553052 0.74 MEN1 (0.83) MEN1APAF1NPC1LMNAHTT
SCHEMBL12553042 0.74 MEN1 (0.83) MEN1APAF1NPC1LMNAHTT
SCHEMBL18073335 0.74 NPC1 (0.83) MEN1APAF1NPC1LMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed