SCHEMBL16601828

SCHEMBL16601828

O=C1c2ccccc2C(=O)c2cc(-c3ccc(S)cc3)ccc21

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.60
RAB9A P51151 6/20 0.60
SMN1; SMN2 Q16637 5/20 0.60
MEN1 O00255 4/20 0.60
KMT2A Q03164 4/20 0.60
LMNA P02545 4/20 0.60
L3MBTL1 Q9Y468 3/20 0.60
MAPT P10636 3/20 0.60
APAF1 O14727 3/20 0.60
HTT P42858 3/20 0.60
GALK1 P51570 3/20 0.60
BLM P54132 3/20 0.60
NPSR1 Q6W5P4 3/20 0.60
PTBP1 P26599 2/20 0.60
SMAD3 P84022 2/20 0.60
THRB P10828 2/20 0.60
XBP1 P17861 1/20 0.60
ATM Q13315 1/20 0.60
PTPRC P08575 9/20 0.50
PTPN1 P18031 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28863139 0.87 NPC1 (0.68) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL21993324 0.85 NPC1 (0.80) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL16601666 0.85 MEN1 (0.61) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL57813 0.85 NPC1 (0.80) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL30722379 0.85 NPC1 (0.80) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL7322266 0.83 MEN1 (0.84) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL1482692 0.83 MEN1 (0.84) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL5159657 0.83 MEN1 (0.57) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL12553052 0.83 MEN1 (0.83) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL4410719 0.83 MEN1 (0.76) NPC1RAB9ASMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed