SCHEMBL16601967

SCHEMBL16601967

CNc1cccc(-c2ccc3c(c2)-c2cc(C)ccc2C(=C(C#N)C#N)C3=O)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP2 O95551 2/20 0.35
ELANE P08246 1/20 0.35
ALKBH3 Q96Q83 1/20 0.35
BRD4 O60885 2/20 0.34
NPC1 O15118 2/20 0.34
MAPT P10636 2/20 0.34
RAB9A P51151 2/20 0.34
LMNA P02545 2/20 0.34
THRB P10828 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
MEN1 O00255 1/20 0.34
APAF1 O14727 1/20 0.34
XBP1 P17861 1/20 0.34
PTBP1 P26599 1/20 0.34
HTT P42858 1/20 0.34
GALK1 P51570 1/20 0.34
BLM P54132 1/20 0.34
SMAD3 P84022 1/20 0.34
KMT2A Q03164 1/20 0.34
ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16656336 0.84 MAOA (0.41) ELANEALKBH3NPC1MAPTRAB9A
SCHEMBL12113759 0.81 MAOA (0.48) ELANEALKBH3MAPTMEN1KMT2A
SCHEMBL16602029 0.78 PTGS1 (0.38) ELANEALKBH3NPC1MAPTRAB9A
SCHEMBL16656339 0.76 MAPT (0.42) ELANEALKBH3NPC1MAPTRAB9A
SCHEMBL16602009 0.75 TDP2 (0.43) TDP2NPC1MAPTRAB9ALMNA
SCHEMBL16601980 0.75 ALKBH3 (0.36) ELANEALKBH3NPC1MAPTRAB9A
SCHEMBL12590260 0.74 CYP2A6 (0.40) ELANEALKBH3NPC1MAPTRAB9A
SCHEMBL12113903 0.73 MAPT (0.49) ELANEMAPTMEN1KMT2AUSP8
SCHEMBL16601966 0.72 MAPT (0.42) MAPTMEN1KMT2AUSP8USP7
SCHEMBL16602022 0.72 EGFR (0.43) TDP2NPC1MAPTRAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed