Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.41 |
| ▸ | HTR2B | P41595 | 6/20 | 0.41 |
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28618675 | 0.89 | HTR2C (0.44) | HTR2CHTR2BHTR2ASLC6A4ADRB1 | |
| SCHEMBL7897325 | 0.78 | CMA1 (0.43) | HTR2CHTR2BHTR2ASLC6A4ADRB1 | |
| SCHEMBL10841091 | 0.77 | HTR2C (0.41) | HTR2CHTR2BHTR2ASLC6A4ADRB1 | |
| SCHEMBL29659975 | 0.77 | HTR2C (0.41) | HTR2CHTR2BHTR2ASLC6A4ADRB1 | |
| SCHEMBL166058 | 0.77 | MAPT (0.43) | MAPT | |
| SCHEMBL30853463 | 0.71 | HTR2A (0.47) | HTR2CHTR2BHTR2ASLC6A4ADRB1 | |
| SCHEMBL3873031 | 0.71 | HTR2A (0.47) | HTR2CHTR2BHTR2ASLC6A4ADRB1 | |
| SCHEMBL23812633 | 0.70 | TSHR (0.41) | MAPT | |
| Hydrochloric Acid SCHEMBL11332118 | 0.70 | HTR2C (0.39) | HTR2CHTR2BHTR2AHTR1AADRA2A | |
| SCHEMBL25058873 | 0.69 | HTR2A (0.46) | HTR2CHTR2BHTR2ASLC6A4ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |