Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23812633 | 0.93 | TSHR (0.41) | MAPTBRD4CREBBPEP300MTNR1A | |
| SCHEMBL424121 | 0.88 | MTNR1A (0.45) | MAPTBRD4CREBBPEP300MTNR1A | |
| SCHEMBL29683355 | 0.88 | MTNR1A (0.45) | MAPTBRD4CREBBPEP300MTNR1A | |
| SCHEMBL4130897 | 0.88 | MTNR1A (0.45) | MAPTBRD4CREBBPEP300MTNR1A | |
| SCHEMBL29641564 | 0.88 | MTNR1A (0.45) | MAPTBRD4CREBBPEP300MTNR1A | |
| SCHEMBL1734662 | 0.88 | MTNR1A (0.45) | MAPTBRD4CREBBPEP300MTNR1A | |
| Ammonia Solution, Strong SCHEMBL5054545 | 0.86 | MTNR1A (0.44) | MAPTBRD4CREBBPEP300MTNR1A | |
| SCHEMBL5420694 | 0.77 | MAPT (0.43) | MAPTMTNR1ATSHRNPC1MAPK13 | |
| SCHEMBL28901934 | 0.77 | MAPT (0.43) | MAPTMTNR1ATSHRNPC1MAPK13 | |
| SCHEMBL23392198 | 0.77 | MAPT (0.43) | MAPTMTNR1ATSHRNPC1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |