Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.60 |
| ▸ | KDR | P35968 | 7/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.60 |
| ▸ | RET | P07949 | 4/20 | 0.60 |
| ▸ | ABL1 | P00519 | 3/20 | 0.60 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.60 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.60 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | FYN | P06241 | 2/20 | 0.60 |
| ▸ | LYN | P07948 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659561 | 0.90 | RAF1 (0.61) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL1660161 | 0.89 | RAF1 (0.63) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL1660130 | 0.89 | RAF1 (0.58) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL1662323 | 0.89 | RAF1 (0.75) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL1660855 | 0.88 | RAF1 (0.82) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL14453671 | 0.87 | RAF1 (0.63) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL1660436 | 0.87 | RAF1 (0.67) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL1660281 | 0.86 | RAF1 (0.69) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL16620832 | 0.84 | RAF1 (0.74) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL5564844 | 0.82 | RAF1 (0.60) | RAF1EPHX2KDRMAPK14RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |