Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.58 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | MUSK | O15146 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | PDE6D | O43924 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660291 | 0.90 | MAPK14 (0.47) | RAF1KDREPHX2BRAFPDGFRA | |
| SCHEMBL1660368 | 0.89 | RAF1 (0.63) | RAF1KDREPHX2BRAFPDGFRA | |
| SCHEMBL1658903 | 0.89 | RAF1 (0.54) | RAF1KDREPHX2BRAFPDGFRA | |
| SCHEMBL1661121 | 0.88 | RAF1 (0.61) | RAF1KDRPDGFRAMEN1CSF1R | |
| SCHEMBL1662287 | 0.87 | RAF1 (0.66) | RAF1KDREPHX2BRAFMEN1 | |
| SCHEMBL1659083 | 0.86 | RAF1 (0.64) | RAF1KDREPHX2BRAFPDGFRA | |
| SCHEMBL1660245 | 0.85 | RAF1 (0.68) | RAF1KDREPHX2BRAFPDGFRA | |
| SCHEMBL1659561 | 0.79 | RAF1 (0.61) | RAF1KDREPHX2BRAFPDGFRA | |
| SCHEMBL1660399 | 0.79 | ABL1 (0.46) | RAF1KDREPHX2BRAFPDGFRA | |
| SCHEMBL1662382 | 0.79 | DDR2 (0.51) | RAF1KDREPHX2BRAFPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |