Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.53 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16603991 | 0.86 | AGER (1.00) | AGERMAPTMCOLN3C5AR1CA9 | |
| SCHEMBL12180441 | 0.86 | AGER (0.71) | AGERMAPTMCOLN3C5AR1CA9 | |
| SCHEMBL10911759 | 0.77 | AGER (0.59) | AGERMAPTMCOLN3C5AR1CA9 | |
| SCHEMBL23054306 | 0.76 | AGER (0.62) | AGERMAPTMCOLN3C5AR1CA9 | |
| SCHEMBL563082 | 0.75 | AGER (0.62) | AGERMAPTMCOLN3C5AR1CA9 | |
| SCHEMBL26413518 | 0.74 | MAPT (0.65) | AGERMAPTMCOLN3C5AR1CA9 | |
| SCHEMBL5880406 | 0.74 | MAPT (0.65) | AGERMAPTMCOLN3C5AR1CA9 | |
| SCHEMBL82589 | 0.74 | MAPT (0.65) | AGERMAPTMCOLN3C5AR1CA9 | |
| SCHEMBL29963641 | 0.73 | APOBEC3G (0.60) | AGERMAPTMCOLN3C5AR1CA9 | |
| SCHEMBL30082691 | 0.73 | AGER (0.59) | AGERMAPTMCOLN3C5AR1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-9364472-B2 | Amino, Amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | NEW YORK UNIVERSITY (US) | 2016-06-14 | — | — | US | disclosed |
| US-9353078-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | NEW YORK UNIVERSITY (US) | 2016-05-31 | — | — | US | disclosed |
| US-20160101096-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-04-14 | — | — | US | disclosed |
| US-20150094307-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2015-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094307-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | AGER 1/4885MAPT 1914/4885MCOLN3 4095/4885 |
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | AGER 1/4885MAPT 1914/4885MCOLN3 4095/4885 |
| US-20160101096-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | AGER 1/4885MAPT 1914/4885MCOLN3 4095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.