Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734662 | 1.00 | MTNR1A (0.45) | MTNR1ABRD4CREBBPEP300SMYD3 | |
| SCHEMBL29683355 | 1.00 | MTNR1A (0.45) | MTNR1ABRD4CREBBPEP300SMYD3 | |
| SCHEMBL424121 | 1.00 | MTNR1A (0.45) | MTNR1ABRD4CREBBPEP300SMYD3 | |
| SCHEMBL29641564 | 1.00 | MTNR1A (0.45) | MTNR1ABRD4CREBBPEP300SMYD3 | |
| Ammonia Solution, Strong SCHEMBL5054545 | 0.98 | MTNR1A (0.44) | MTNR1ABRD4CREBBPEP300SMYD3 | |
| SCHEMBL166058 | 0.88 | MAPT (0.43) | MTNR1ABRD4CREBBPEP300NPC1 | |
| SCHEMBL23812633 | 0.85 | TSHR (0.41) | MTNR1ABRD4CREBBPEP300NPC1 | |
| SCHEMBL22383643 | 0.80 | MTNR1A (0.43) | MTNR1ABRD4CREBBPSMYD3NPC1 | |
| SCHEMBL19774297 | 0.78 | MTNR1A (0.47) | MTNR1ASMYD3NPC1MAPK13MAPK12 | |
| SCHEMBL1736809 | 0.78 | CREBBP (0.55) | BRD4CREBBPEP300TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114591369-B | Phosphoramidite ligand and preparation method and application thereof | 中国科学院大连化学物理研究所 | 2024-05-10 | — | — | CN | disclosed |
| CN-114591369-A | Phosphoramidite ligand and preparation method and application thereof | 中国科学院大连化学物理研究所 | 2022-06-07 | — | — | CN | disclosed |
| CN-109336887-B | Benzimidazole chiral heterocyclic compound and preparation method and application thereof | 中山大学 | 2021-12-17 | — | — | CN | disclosed |
| CN-109575060-B | Synthesis of spiro bisboron catalyst and application of spiro bisboron catalyst in hydrogenation reaction | 南开大学 | 2020-11-17 | — | — | CN | disclosed |
| US-10565015-B2 | Spiroketal-based C2-symmetric scaffold for asymmetric catalysis | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-02-18 | — | — | US | disclosed |
| US-20190084995-A1 | Spiroketal-Based C2-Symmetric Scaffold For Asymmetric Catalysis | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-03-21 | — | — | US | disclosed |
| CN-109336887-A | A kind of benzimidazole and chiral heterocycle class compound and its preparation method and application | 中山大学 | 2019-02-15 | — | — | CN | disclosed |
| WO-2015040424-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND THEIR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS | VERNALIS (R&D) LIMITED (GB) | 2015-03-26 | — | — | WO | disclosed |
| WO-2015040424-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND THEIR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS | VERNALIS (R&D) LIMITED (GB) | 2015-03-26 | — | — | WO | disclosed |
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2009-09-24 | — | — | US | disclosed |
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2009-09-24 | — | — | US | disclosed |
| US-20090111760-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-04-30 | — | — | US | disclosed |
| EP-1824869-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006050941-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111760-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | MTNR1A 3171/4885BRD4 2030/4885CREBBP 3384/4885 |
| US-10565015-B2 | Spiroketal-based C2-symmetric scaffold for asymmetric catalysis | PKD2, OPA1, PKD1 | MTNR1A 2780/4885BRD4 2706/4885CREBBP 4577/4885 |
| US-20190084995-A1 | Spiroketal-Based C2-Symmetric Scaffold For Asymmetric Catalysis | PKD2, OPA1, PKD1 | MTNR1A 2780/4885BRD4 2706/4885CREBBP 4577/4885 |
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | HTR2C, HTR2A, DRD2 | MTNR1A 256/4885BRD4 505/4885CREBBP 1534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.