SCHEMBL16606252

SCHEMBL16606252

CC(C)Oc1cc(OC(C)C)c(Cl)cc1Cl

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 2/20 0.52
GAA P10253 3/20 0.49
RORC P51449 1/20 0.46
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
PPOX P50336 2/20 0.43
NR1I2 O75469 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 1/20 0.42
POLB P06746 1/20 0.42
HPGD P15428 1/20 0.42
TSHR P16473 1/20 0.42
HSD17B10 Q99714 1/20 0.42
S1PR1 P21453 4/20 0.41
S1PR3 Q99500 1/20 0.41
MAPK1 P28482 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13019313 0.92 CSNK2A1 (0.50) CSNK2A1GAARORCMEN1KMT2A
SCHEMBL22268449 0.91 GAA (0.52) CSNK2A1GAARORCMEN1KMT2A
SCHEMBL14198845 0.86 CSNK2A1 (0.46) CSNK2A1GAARORCMEN1KMT2A
SCHEMBL30776065 0.84 GAA (0.46) CSNK2A1GAARORCMEN1KMT2A
SCHEMBL14209033 0.84 GAA (0.46) CSNK2A1GAARORCMEN1KMT2A
SCHEMBL3277991 0.84 NPC1 (0.61) CSNK2A1GAARORCMEN1KMT2A
SCHEMBL31291610 0.84 CSNK2A1 (0.44) CSNK2A1GAARORCMEN1KMT2A
SCHEMBL19088281 0.84 CSNK2A1 (0.44) CSNK2A1GAARORCMEN1KMT2A
SCHEMBL29145277 0.84 CSNK2A1 (0.44) CSNK2A1GAARORCMEN1KMT2A
SCHEMBL23183252 0.83 CSNK2A1 (0.47) CSNK2A1GAARORCMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10364217-B2 Chemical compounds RESMAN AS (NO) 2019-07-30 US disclosed
US-20160214930-A1 CHEMICAL COMPOUNDS RESMAN AS (NO) 2016-07-28 US disclosed
US-20150094240-A1 CHEMICAL COMPOUNDS RESMAN AS (NO) 2015-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160214930-A1 CHEMICAL COMPOUNDS PTGES, PTGIS, PTGFR CSNK2A1 4552/4885GAA 1448/4885RORC 894/4885
US-20150094240-A1 CHEMICAL COMPOUNDS PTGES, PTGIS, PTGFR CSNK2A1 4552/4885GAA 1448/4885RORC 894/4885
US-10364217-B2 Chemical compounds PTGES, PTGIS, PTGFR CSNK2A1 4552/4885GAA 1448/4885RORC 894/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.