Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | SDHB | P21912 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | STAT3 | P40763 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19772938 | 0.90 | BPTF (0.35) | BPTFSDHBHPGDNPSR1LMNA | |
| SCHEMBL17995491 | 0.88 | BPTF (0.34) | BPTFSDHBHPGDNPSR1LMNA | |
| SCHEMBL19772981 | 0.83 | BPTF (0.33) | BPTFSDHBHPGDNPSR1LMNA | |
| SCHEMBL16608872 | 0.79 | RIPK1 (0.40) | BPTFSDHBHPGDNPSR1LMNA | |
| SCHEMBL16608412 | 0.79 | RIPK1 (0.40) | BPTFSDHBHPGDNPSR1LMNA | |
| SCHEMBL9626200 | 0.72 | LMNA (0.52) | BPTFSDHBHPGDNPSR1LMNA | |
| SCHEMBL19772956 | 0.71 | ADORA2A (0.34) | SDHBLMNAHTTKMT2ARAB9A | |
| SCHEMBL17995494 | 0.71 | RIPK1 (0.34) | SDHBHPGDKMT2ATP53RAB9A | |
| SCHEMBL17995493 | 0.71 | RIPK1 (0.34) | SDHBHPGDKMT2ATP53RAB9A | |
| SCHEMBL19772954 | 0.71 | ADORA2A (0.34) | SDHBLMNAHTTKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015048246-A1 | TETRA-ARYL CYCLOBUTANE INHIBITORS OF ANDROGEN RECEPTOR ACTION FOR THE TREATMENT OF HORMONE REFRACTORY CANCER | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2015-04-02 | — | — | WO | disclosed |