Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.49 |
| ▸ | MEN1 | O00255 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9647595 | 0.85 | MAPT (0.60) | MAPTALOX15KMT2AMEN1LMNA | |
| SCHEMBL16608984 | 0.83 | MEN1 (0.54) | MAPTALOX15KMT2AMEN1NPC1 | |
| SCHEMBL26436184 | 0.83 | MAPT (0.57) | MAPTALOX15KMT2AMEN1NPC1 | |
| SCHEMBL4218044 | 0.82 | MAPT (0.61) | MAPTALOX15KMT2AMEN1AKR1C3 | |
| SCHEMBL16645313 | 0.81 | HDAC1 (0.57) | MAPTALOX15KMT2AMEN1RAB9A | |
| SCHEMBL28901159 | 0.81 | MAPT (0.55) | MAPTALOX15KMT2AMEN1LMNA | |
| SCHEMBL28901163 | 0.81 | MAPK13 (0.63) | MAPTALOX15KMT2AMEN1NPC1 | |
| SCHEMBL29116429 | 0.81 | SMN1; SMN2 (0.51) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4238913 | 0.81 | RAB9A (0.66) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL29151820 | 0.81 | MAPT (0.51) | MAPTALOX15KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073468-B | Preparation and application of imidazopyrazines BTK inhibitor | 药雅科技(上海)有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-115073468-A | Preparation and application of imidazopyrazine BTK inhibitor | 药雅科技(上海)有限公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2015048306-A1 | NOVEL AGENTS TARGETING CYP51 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |