Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CFTR | P13569 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845029 | 0.87 | MAPK14 (0.54) | HDAC1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7200687 | 0.83 | MAPK14 (0.76) | HDAC1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL21463821 | 0.82 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11HSD17B10 | |
| SCHEMBL30615339 | 0.82 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11HSD17B10 | |
| SCHEMBL16608985 | 0.81 | MAPT (0.55) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL27482085 | 0.81 | MAPK13 (0.72) | HDAC1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6812866 | 0.81 | MAPK14 (0.81) | HDAC1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL22101263 | 0.77 | RAB9A (0.47) | ALDH1A1MAPTALOX15KDM4EMEN1 | |
| SCHEMBL3499186 | 0.77 | SIRT2 (0.68) | HDAC1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2314122 | 0.76 | HSD17B10 (0.68) | MAPK14MAPK13MAPK12MAPK11HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |