Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA7 | P43166 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 3/20 | 0.47 |
| ▸ | ESR1 | P03372 | 3/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9143243 | 0.87 | CA12 (0.54) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2941745 | 0.85 | SLC6A3 (0.57) | KDM4EHSD17B10CA12CA1CA2 | |
| SCHEMBL30765671 | 0.83 | NR4A2 (0.55) | LMNAKDM4EGAASMN1; SMN2SLC6A4 | |
| SCHEMBL4651623 | 0.83 | NR4A2 (0.55) | LMNAKDM4EGAASMN1; SMN2SLC6A4 | |
| SCHEMBL2296342 | 0.82 | KDM4E (0.58) | LMNAKDM4ECA1CA2SMN1; SMN2 | |
| SCHEMBL38655411 | 0.82 | GAA (0.54) | KDM4EHSD17B10CA12CA1CA2 | |
| SCHEMBL31547607 | 0.82 | SLC6A3 (0.47) | KDM4EHSD17B10CA12CA1CA2 | |
| SCHEMBL4898484 | 0.81 | PDK2 (0.42) | LMNAKDM4EHSD17B10CA12CA1 | |
| SCHEMBL10004074 | 0.80 | CYP46A1 (0.49) | LMNAKDM4ECA12CA1CA2 | |
| SCHEMBL17996053 | 0.80 | CFTR (0.47) | LMNAKDM4EGAAERN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015048306-A1 | NOVEL AGENTS TARGETING CYP51 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |