Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18012185 | 0.87 | GABRG2 (0.41) | GPR119MAPTGABRG2GABRB3GABRA5 | |
| SCHEMBL16610290 | 0.84 | GABRG2 (0.39) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL16268180 | 0.82 | GABRG2 (0.38) | GPR119MAPTGABRG2GABRB3GABRA5 | |
| SCHEMBL20129203 | 0.82 | NR1H2 (0.41) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL20133366 | 0.79 | GPR119 (0.42) | GPR119GABRG2GABRB3GABRA5PIK3CD | |
| SCHEMBL29547275 | 0.79 | GPR119 (0.38) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL29773812 | 0.79 | NR1H2 (0.38) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL20120812 | 0.79 | NR1H2 (0.38) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL31411068 | 0.79 | GPR119 (0.38) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL29547450 | 0.79 | NR1H2 (0.38) | GPR119GABRG2GABRB3GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015047902-A1 | COMPOUNDS AND THEIR USE FOR PREPARATION OF TAU IMAGING AGENTS AND TAU IMAGING FORMULATIONS | ELI LILLY AND COMPANY (US) | 2015-04-02 | — | — | WO | disclosed |