Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 13/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15771417 | 0.85 | MAPT (0.46) | CYP46A1NPY5RCA12CA1CA2 | |
| SCHEMBL16622465 | 0.81 | SIGMAR1 (0.47) | CYP46A1NPY5RCACNA2D1CA12CA1 | |
| SCHEMBL785159 | 0.78 | F10 (0.51) | NPY5R | |
| SCHEMBL13622696 | 0.76 | FFAR4 (0.48) | CA12CA1CA2CA9 | |
| SCHEMBL20755270 | 0.76 | GAA (0.46) | ROCK2PRKG1CDK8CA12CA1 | |
| SCHEMBL25246297 | 0.75 | USP30 (0.44) | CYP46A1 | |
| SCHEMBL19555543 | 0.75 | CHRM4 (0.54) | CYP46A1CDK8 | |
| SCHEMBL785732 | 0.74 | GPR119 (0.52) | CYP46A1CCNCCDK8 | |
| SCHEMBL784900 | 0.73 | MCHR1 (0.46) | CCNCCDK8 | |
| SCHEMBL15718658 | 0.72 | FFAR1 (0.51) | NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857388-A1 | Azoles containing sulfone | Grünenthal GmbH (DE) | 2015-04-08 | — | — | EP | disclosed |