Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596398 | 1.00 | HRH3 (0.47) | HRH3KCNH2CYP3A4 | |
| SCHEMBL12181955 | 0.95 | HRH3 (0.48) | HRH3KCNH2CYP3A4 | |
| SCHEMBL16612931 | 0.84 | HRH3 (0.46) | HRH3KCNH2CYP3A4 | |
| SCHEMBL12181943 | 0.84 | HRH3 (0.46) | HRH3KCNH2CYP3A4 | |
| SCHEMBL14736897 | 0.84 | HRH3 (0.46) | HRH3KCNH2CYP3A4 | |
| SCHEMBL12181944 | 0.81 | GPR119 (0.40) | HRH3KCNH2 | |
| SCHEMBL12182151 | 0.77 | GRIN2D (0.51) | HRH3KCNH2CYP3A4 | |
| SCHEMBL2596385 | 0.77 | HRH3 (0.43) | HRH3KCNH2CYP3A4 | |
| SCHEMBL12182110 | 0.77 | HRH3 (0.44) | HRH3KCNH2CYP3A4 | |
| SCHEMBL4980370 | 0.76 | HRH3 (0.40) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569305-B1 | SUBSTITUTED N-HETEROARYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2015-04-08 | — | — | EP | claimed |