Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28999635 | 0.79 | MAOB (0.54) | HDAC1HDAC6HDAC5MAOBAPP | |
| SCHEMBL113439 | 0.78 | P4HTM (0.58) | HDAC6MAOB | |
| SCHEMBL115662 | 0.77 | SLC6A4 (0.40) | — | |
| SCHEMBL114283 | 0.77 | SLC6A4 (0.39) | — | |
| SCHEMBL9558824 | 0.75 | MAOB (0.56) | PTPRZ1MAOBAPP | |
| SCHEMBL8355718 | 0.75 | MAOB (0.56) | PTPRZ1MAOBAPP | |
| SCHEMBL9558763 | 0.75 | APP (0.62) | PTPRZ1MAOBAPP | |
| SCHEMBL24099577 | 0.73 | PTPRZ1 (0.46) | PTPRZ1MAOBAPP | |
| SCHEMBL9558102 | 0.73 | APP (0.61) | PTPRZ1MAOBAPP | |
| SCHEMBL9557834 | 0.73 | MAOB (0.61) | PTPRZ1MAOBAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | disclosed |