Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115662 | 0.86 | SLC6A4 (0.40) | SLC6A4CYP11B1CYP11B2MAOASLC6A2 | |
| SCHEMBL9158077 | 0.79 | TAAR1 (0.43) | CYP11B1CYP11B2HTR2AKCNH2NPC1 | |
| SCHEMBL9156125 | 0.79 | SMN1; SMN2 (0.46) | CYP11B1CYP11B2HTR2AKCNH2NPC1 | |
| SCHEMBL1713352 | 0.78 | — | — | |
| SCHEMBL16613185 | 0.77 | PTPRZ1 (0.45) | — | |
| SCHEMBL9154293 | 0.76 | NFKB1 (0.51) | SLC6A4SLC6A2SLC6A3HTR2ANPC1 | |
| SCHEMBL9154340 | 0.75 | NPC1 (0.40) | CYP11B1CYP11B2HTR2AKCNH2NPC1 | |
| SCHEMBL9156732 | 0.75 | RAB9A (0.50) | CYP11B1CYP11B2HTR2AKCNH2NPC1 | |
| SCHEMBL115480 | 0.75 | CYP1A1 (0.49) | HTR2AKCNH2NPC1RAB9AMEN1 | |
| SCHEMBL9154167 | 0.75 | RAB9A (0.49) | SLC6A4SLC6A2SLC6A3HTR2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |