SCHEMBL1661418

SCHEMBL1661418

C#CCOC(=O)CC[C@H](N)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A1 P43005 3/20 0.48
GRIK1 P39086 3/20 0.48
GRIK2 Q13002 3/20 0.48
SLC1A3 P43003 2/20 0.48
SLC1A2 P43004 2/20 0.48
GSR P00390 2/20 0.48
GRM8 O00222 1/20 0.48
GRM6 O15303 1/20 0.48
GRIN2D O15399 1/20 0.48
GRIN3B O60391 1/20 0.48
CYP1A2 P05177 1/20 0.48
GRM5 P41594 1/20 0.48
GRIA1 P42261 1/20 0.48
GRIA2 P42262 1/20 0.48
GRIA3 P42263 1/20 0.48
GRIA4 P48058 1/20 0.48
GRIN1 Q05586 1/20 0.48
GRIN2A Q12879 1/20 0.48
GRIK3 Q13003 1/20 0.48
GRIN2B Q13224 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3289233 1.00 SLC1A1 (0.48) SLC1A1GRIK1GRIK2SLC1A3SLC1A2
SCHEMBL15509381 0.87 GSTP1 (0.41) SLC1A1GRIK1GRIK2SLC1A3SLC1A2
SCHEMBL1661419 0.87 GSTP1 (0.41) SLC1A1GRIK1GRIK2SLC1A3SLC1A2
SCHEMBL28063444 0.85 GSTP1 (0.38) SLC1A1GRIK1GRIK2SLC1A3SLC1A2
SCHEMBL4230332 0.82 SLC1A2 (0.48) SLC1A1GRIK1GRIK2SLC1A3SLC1A2
SCHEMBL3289350 0.81 GRIK1 (0.47) SLC1A1GRIK1GRIK2SLC1A3SLC1A2
SCHEMBL29410188 0.79 GSR (0.46) SLC1A1GRIK1GRIK2SLC1A3SLC1A2
SCHEMBL28945063 0.79 GSR (0.46) SLC1A1GRIK1GRIK2SLC1A3SLC1A2
SCHEMBL10453103 0.77 GSR (0.56) SLC1A1GRIK1GRIK2SLC1A3SLC1A2
SCHEMBL1064949 0.77 SLC1A1 (0.56) SLC1A1GRIK1GRIK2SLC1A3SLC1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115010919-B Polypeptide, nano switch based on polypeptide, and preparation method and application of nano switch 苏州大学 2023-11-24 CN disclosed
CN-115364240-A Gate-controlled nanoparticle based on polypeptide and preparation method and application thereof 苏州大学 2022-11-22 CN disclosed
US-20170079928-A1 COPOLYMERS OF FORMULA (I) AND USES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS (FR) 2017-03-23 US disclosed
US-20170079928-A1 COPOLYMERS OF FORMULA (I) AND USES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS (FR) 2017-03-23 US disclosed
WO-2015181504-A1 COPOLYMERS OF FORMULA (I) AND USES LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES (FR) 2015-12-03 WO disclosed
EP-2493868-A2 POLY(PROPARGYL-L-GLUTAMATE) AND DERIVATIVES THEREOF Massachusetts Institute Of Technology (US) 2012-09-05 EP disclosed
US-8222359-B2 Poly(propargyl-L-glutamate) and derivatives thereof MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2012-07-17 US disclosed
WO-2011056645-A2 POLY(PROPARGYL-L-GLUTAMATE) AND DERIVATIVES THEREOF MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2011-05-12 WO disclosed
US-20110097419-A1 Poly(Propargyl-L-Glutamate) and Derivatives Thereof MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2011-04-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110097419-A1 Poly(Propargyl-L-Glutamate) and Derivatives Thereof GLUL, QPCTL, QPCT SLC1A1 105/4885GRIK1 36/4885GRIK2 47/4885
US-20170079928-A1 COPOLYMERS OF FORMULA (I) AND USES MSR1, ASGR1, FCGR3B SLC1A1 2587/4885GRIK1 339/4885GRIK2 903/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.