Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11449475 | 0.79 | CYP3A4 (0.47) | CYP3A4ACHEKDM4ETDP1HPGD | |
| SCHEMBL3944204 | 0.79 | KDM4E (0.62) | CYP3A4ACHEKDM4ETDP1HPGD | |
| SCHEMBL25148647 | 0.77 | KDM4E (0.53) | KDM4ETDP1GAAAPPMAPT | |
| SCHEMBL27854556 | 0.75 | KDM4E (0.45) | CYP3A4ACHEKDM4ETDP1HPGD | |
| SCHEMBL27836676 | 0.72 | PTPN1 (0.50) | KDM4EHPGDHSD17B10GAAPTPN1 | |
| SCHEMBL5174549 | 0.72 | GPR35 (0.44) | KDM4ETDP1HPGDHSD17B10GAA | |
| SCHEMBL1658709 | 0.70 | ALDH1A1 (0.42) | CYP3A4ACHEKDM4EHPGDHSD17B10 | |
| SCHEMBL28062208 | 0.68 | CYP3A4 (0.52) | CYP3A4ACHEKDM4ETDP1HPGD | |
| SCHEMBL10261582 | 0.67 | PDPK1 (0.34) | KDM4EMAPTBAZ2B | |
| SCHEMBL21416134 | 0.67 | ALDH1A1 (0.39) | CYP3A4ACHEKDM4ETDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306828-A1 | PROLYL HYDROXYLASE INHIBITORS | Glaxosmithkline LLC (US) | 2011-04-13 | — | — | EP | disclosed |